J.J. McCarthy’s high-ankle sprain sidelines Minnesota’s rookie QB for 2-4 weeks, elevating Carson Wentz to the starting role as Minnesota drops to 1-1 after a 22-6 SNF loss to Atlanta. The Vikings’ next test comes against Cincinnati, a team juggling its own QB situation. Fantasy managers should reassess Vikings pass-game expectations with Wentz under center and gauge how the Bengals’ QB instability might shape this Week 3-4 slate.

Sunday’s 1 p.m. game brings two starting QBs out of the mix for Minnesota and Cincinnati. J.J. McCarthy is sidelined with an ankle, and Aaron Jones is out with a hamstring, forcing Carson Wentz to start for Minnesota and Jordan Mason to carry the Bengals’ ground game. Wentz’s veteran presence and big-arm track record could stabilize the Vikings’ attack, while Mason faces a backfield-by-committee vibe with limited but meaningful volume. Fantasy managers should weigh Wentz as a safer streamer option and Mason as a plausible RB3/flex depending on game flow, especially with no betting lines in play as of now.

Colts top Broncos in a playoff-tight AFC clash as Daniel Jones dazzles with 316 passing yards and a rushing TD, while Nick Cross and Cam Bynum anchor the secondary. Xavien Howard struggles with penalties and coverage, and Spencer Shrader irons out the kicking game until a late 60-yard try is wiped by a penalty and a game-ending 45-yard winner. Indy’s discipline must improve after a slate of penalties, with a big test coming in Tennessee.

Week 2 injuries create a shifting fantasy landscape. Burrow’s turf-toe surgery sinks Cincinnati’s ceiling and thrusts Browning into a tough starter role. Fields’ concussion protocol and Daniels’ knee sprain keep multiple offenses in flux, while Ekeler’s season-ending Achilles reshapes Washington’s backfield. IRs for Hunt and Corbett and Beebe’s high-ankle out the Cowboys’ center and Panthers’ line, respectively, heighten concerns. Several top corners (Surtain II, Terrell, Johnson) carry medium to high risk, influencing matchup decisions across the league.